LMDE is Linux Mint’s Debian based edition, which is usually faster and more stable than the normal editions based on Ubuntu.

New features in LMDE 4

  • Automated partitioning with support for LVM and full-disk encryption
  • Home directory encryption
  • Support for automated installation of NVIDIA drivers
  • NVMe support
  • SecureBoot support
  • Btrfs subvolumes support
  • Revamped installer
  • Automatic installation of microcode packages
  • Automatic resolution bump for the live session to a minimum of 1024×768 in Virtualbox.
  • Linux Mint 19.3 improvements (HDT, Boot-repair, System reports, language settings, HiDPI and artwork improvements, new boot menus, Celluloid, Gnote, Drawing, Cinnamon 4.4, XApp status icons…etc)
  • APT recommends enabled by default
  • Removed deb-multimedia repository and packages
  • Debian 10 Buster package base with backports repository

More info in the official announcement.